Drug name: Verteporfin


Related CSCTT Targets

YAP1 [ref.1]P46937

Verteporfin

Cas.no PubChem ID
142878-05-5, 129497-78-5 11980904
Known Target
YAP1P46937
Introduction
Combined by Bpd-ma(sub d) and Visudyne. Verteporfin (trade name Visudyne), a benzoporphyrin derivative, is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 689 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels. Verteporfin is also used off-label for the treatment of central serous retinopathy.

Verteporfin-Structure

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Reference

  • [1] Targeting an Autocrine Regulatory Loop in Cancer Stem-like Cells Impairs the Progression and Chemotherapy Resistance of Bladder Cancer.
    Clin Cancer Res. 2019 Feb 1;25(3):1070-1086.. [ 30397177 ]

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