Drug name: hCD271 mAb


Related CSCTT Targets

CD271 [ref.1]P08138

Humanized anti-CD271 monoclonal antibody

Cas.no PubChem ID
Not Detected
Known Target
CD271P08138
Introduction
hCD271 mA b bound to the cysteine-rich domain 1 (CRD1) of human CD271 with high affinity (KD = 1.697 × 10−9 M). In vitro, hCD271 mA b exerted antibody-dependent cell-mediated cytotoxicity (ADCC) activity against SP2/0-CD271 (human CD271-transduced mouse cell line). Treatment with hCD271 mA b also exerted anti-tumor activity in graft models of three cell lines (HPCM2 (patient-derived xenograft cell line of hypopharyngeal cancer), MeWo-Luc (melanoma cell line), and SP2/0-CD271) in mice, resulting in smaller tumors compared to controls and reduced numbers of CD271-positive cells.

Humanized anti-CD271 monoclonal antibody-Structure

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Reference

  • [1] Humanized anti-CD271 Monoclonal Antibody Exerts an Anti-Tumor Effect by Depleting Cancer Stem Cells
    Cancer Lett. 2019 Oct 1;461:144-152.. [ 31325530 ]

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