Detail for HIF-2α


Full Name

Hypoxia-inducible factor

Gene Name

GC14P061695

NCBI ID

Related Disease

  • PAN [ref.1]
  • Multiple myeloma [ref.2]

Therapy Method

  • [ref.]

Function

HGF (Hepatocyte Growth Factor) is a Protein Coding gene. Diseases associated with HGF include Deafness, Autosomal Recessive 39 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are ERK Signaling and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include identical protein binding and serine-type endopeptidase activity. An important paralog of this gene is MST1.

Related Pathway/CSCs feature

Reference

  • [1] HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.
    Genes Dev.2006 Mar 1;20(5):557-70.. [ 16510872 ]
  • [2] The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment.
    Cancer Res.2002 Sep 1;62(17):5019-26. [ 12208756 ]

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