Detail for BMP4/TSP1


Full Name

Bone morphogenetic protein 4 /Thrombospondin-1

Gene Name

GC14M053949/GC15P039581

NCBI ID

Related Disease

  • Solid tumors [ref.1]

Therapy Method

  • [ref.]

Function

HGF (Hepatocyte Growth Factor) is a Protein Coding gene. Diseases associated with HGF include Deafness, Autosomal Recessive 39 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are ERK Signaling and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include identical protein binding and serine-type endopeptidase activity. An important paralog of this gene is MST1.

Related Pathway/CSCs feature

Reference

  • [1] BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors.
    Oncogene.2014 Jul 17;33(29):3803-11.. [ 24013228 ]

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