Detail for PI3K/AKT


Full Name

Phosphatidylinositol 3-kinase/protein kinase B

Gene Name

GC01P009711/GC14M104769

NCBI ID

Related Disease

  • Liver cancer [ref.1]

Therapy Method

  • [ref.]

Function

PIK3CD (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta) is a Protein Coding gene. Diseases associated with PIK3CD include Immunodeficiency 14 and Hepatosplenic T-Cell Lymphoma. Among its related pathways are mTOR Pathway and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is PIK3CB.
AKT1 (AKT Serine/Threonine Kinase 1) is a Protein Coding gene. Diseases associated with AKT1 include Cowden Syndrome 6 and Proteus Syndrome. Among its related pathways are ERK Signaling and mTOR Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is AKT3.

Related Pathway/CSCs feature

Reference

  • [1] Curcumin inhibits the growth of liver cancer stem cells through the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway.
    Exp Ther Med.2018 Apr;15(4):3650-3658.. [ 29545895 ]

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