Detail for LGR5

Full Name

Leucine-rich repeat-containing G-protein coupled receptor 5

Gene Name



Related Disease

  • Glioblastoma [ref.1]

Therapy Method

  • [ref.]


LGR5 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 5) is a Protein Coding gene. Diseases associated with LGR5 include Ankyloglossia and Colon Adenoma. Among its related pathways are Signaling by Wnt and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is LGR6.

Related Pathway/CSCs feature


  • [1] LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients.
    J Pathol.2018 Oct 25.. [ 30357839 ]

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