Detail for VDAC1


Full Name

Voltage-dependent anion channel 1

Gene Name

GC05M133975

NCBI ID

Related Disease

  • Glioblastoma [ref.1]

Therapy Method

  • [ref.]

Function

VDAC1 (Voltage Dependent Anion Channel 1) is a Protein Coding gene. Diseases associated with VDAC1 include Cystic Fibrosis and Gerstmann-Straussler Disease. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins and Pink/Parkin Mediated Mitophagy. Gene Ontology (GO) annotations related to this gene include protein kinase binding and voltage-gated anion channel activity. An important paralog of this gene is VDAC2.

Related Pathway/CSCs feature

Reference

  • [1] VDAC1 is a molecular target in glioblastoma, with its depletion leading to reprogrammed metabolism and reversed oncogenic properties.
    Neuro Oncol.2017 Jul 1;19(7):951-964.. [ 28339833 ]

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