Detail for PBX3


Full Name

PBX Homeobox 3

Gene Name

GC09P125747

NCBI ID

Related Disease

  • MLL-rearranged leukemia [ref.1]

Therapy Method

  • [ref.]

Function

PBX3 (PBX Homeobox 3) is a Protein Coding gene. Diseases associated with PBX3 include Childhood Pilocytic Astrocytoma and Pilocytic Astrocytoma. Among its related pathways are Transcriptional misregulation in cancer and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is PBX1.

Related Pathway/CSCs feature

Reference

  • [1] PBX3 is essential for leukemia stem cell maintenance in MLL-rearranged leukemia.
    Int J Cancer.2017 Jul 15;141(2):324-335.. [ 28411381 ]

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