Detail for CHD4


Full Name

Chromodomain-helicase-DNA-binding protein 4

Gene Name

GC12M006570

NCBI ID

Related Disease

  • liver cancer [ref.]

Therapy Method

  • [ref.]

Function

CHD4 (Chromodomain Helicase DNA Binding Protein 4) is a Protein Coding gene. Diseases associated with CHD4 include Sifrim-Hitz-Weiss Syndrome and Cellular Schwannoma. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include hydrolase activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is CHD5.

Related Pathway/CSCs feature

Reference

  • [1] Chromodomain-helicase-DNA-binding protein 4: a novel therapeutic target in liver cancer stem cells.
    Chin Clin Oncol.2017 Feb;6(1):12.. [ 27506807 ]

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