The tumorigenic potential of CD44high/CD24-/low CSCs could be further increased by introducing an additional (fluorescence-activated cell sorting-based) viable cell sorting step, the selection of cells based on high activity of aldehyde dehydrogenase (ALDH).
Related Pathway/CSCs feature
 The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation.
Buijs, J. T., et al. (2012). Oncogene 31(17): 2164-2174. [ 21996751 ]