Drug name: anti-CD3/anti-CD133 bispecific antibodies + NK cells


Related CSCTT Targets

CD133-high CSCs [ref.1]

anti-CD3/anti-CD133 bispecific antibodies

Cas.no PubChem ID
Not Detected Not Detected
Known Target
CD3P04234
CD133O43490
Structure
...
Introduction
A bispecific antibody (BsAb) against CD3 and CD133.

NK cells

Cas.no PubChem ID
Not Detected Not Detected
Known Target
Structure
...
Introduction
Natural killer (NK) cells are a subset of innate immune cells with specified functions in host defense. Typically, immune cells detect major histocompatibility complex (MHC) presented on infected cell surfaces, triggering cytokine release, causing lysis or apoptosis. NK cells are unique, however, as they have the ability to recognize stressed cells in the absence of antibodies and MHC, allowing for a much faster immune reaction. They were named "natural killers" because of the initial notion that they do not require activation to kill cells that are missing self markers of MHC class 1.

Reference

  • [1] Cytokine-induced killer (CIK) cells bound with anti-CD3/anti-CD133 bispecific antibodies target CD133(high) cancer stem cells in vitro and in vivo.
    Huang, J., et al. (2013). Clin Immunol 149(1): 156-168. [ 23994769 ]

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