The lipid nanocapsules (LNCs) are used as drug molecule carriers for cancer treatment. It have been prepared according to an original method based on a phase-inversion temperature processy. Their structure is a hybrid between polymeric nanocapsules and liposomes because of their oily core which is surrounded by a tensioactive rigid membrane. They have a lipoprotein-like structure. Their size can be adjusted below 100 nm with a narrow distribution. Importantly, these properties confer great stability to the structure (physical stability > 18 months). Blank or drug-loaded LNCs can be prepared, with or without PEG (polyethyleneglycol)ylation that is a key parameter that affects the vascular residence time of the nano-cargos. Other hydrophilic tails can also be grafted. Different anticancer drugs (paclitaxel, docetaxel, etoposide, hydroxytamoxifen, doxorubicin, etc.) have been encapsulated. They all are released according to a sustained pattern. Preclinical studies on cell cultures and animal models of tumors have been performed, showing promising results.
Liposomes are composed of vesicular bilayers, lamellae, made of biocompatible and biodegradable lipids such as sphingomyelin, phosphatidylcholine, and glycerophospholipids.
 Huynh, N. T., et al. (2009). "Lipid nanocapsules: A new platform for nanomedicine." Int J Pharm 379(2): 201-209.
 Masserini, M. (2013). "Nanoparticles for brain drug delivery." ISRN biochemistry 2013.