Drug name: Telomestatin + BIBR 1532


Related CSCTT Targets

CD133+ Glioblastoma cells [ref.1]

Telomestatin

Cas.no PubChem ID
265114-54-3 443590
Known Target
DNA
Structure
...
Introduction
Telomestatin is a macrocyclic chemical compound that acts by inhibiting the telomerase activity of the cancer cells. It was first isolated from the bacteria Streptomyces anulatus. Telomestatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. Upon formation of G4 structure there will be a decrease in the activity of the telomerase, which is involved in the replication of the telomeres and as a result the cell dies due to Hayflick type senescence.

BIBR 1532

Cas.no PubChem ID
321674-73-1 9927531
Known Target
Telomerase reverse transcriptaseO14746
Structure
...
Introduction
BIBR1532 is a telomerase inhibitor without G4-stabilizing activity, which had no preferential effect on GSC growth.

Reference

  • [1] G-quadruplex ligand-induced DNA damage response coupled with telomere dysfunction and replication stress in glioma stem cells.
    Hasegawa, D., et al. (2016). Biochem Biophys Res Commun 471(1): 75-81. [ 26845351 ]

Back to top