Drug name: Telomestatin


Related CSCTT Targets

CD133+ Glioblastoma cells [ref.1]

Telomestatin

Cas.no PubChem ID
265114-54-3 443590
Known Target
DNA
Introduction
Telomestatin is a macrocyclic chemical compound that acts by inhibiting the telomerase activity of the cancer cells. It was first isolated from the bacteria Streptomyces anulatus. Telomestatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. Upon formation of G4 structure there will be a decrease in the activity of the telomerase, which is involved in the replication of the telomeres and as a result the cell dies due to Hayflick type senescence.

Telomestatin-Structure

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Reference

  • [1] G-quadruplex ligand-induced DNA damage response coupled with telomere dysfunction and replication stress in glioma stem cells.
    Hasegawa, D., et al. (2016). Biochem Biophys Res Commun 471(1): 75-81. [ 26845351 ]

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