Detail for microRNA 150


Full Name

microRNA 150

Gene Name

MIR150

NCBI ID

Related Disease

  • Liver Cancer [ref.1]

Therapy Method

Function

miR-150 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference.
miR-150 functions in hematopoiesis; it regulates genes whose downstream products encourage differentiating stem cells towards becoming megakaryocytes rather than erythrocytes. It is also thought to control B and T cell differentiation, alongside mir-155.
miR-150 has been linked with a number of cancers including prostate cancer, in which it can be bio-accumulated and also possibly transferred from food sources. It is thought to promote cancer cell proliferation in gastric cancer and has also been found to be more than 50x overexpressed in osteosarcoma. The expression of miR-150 was shown to regulate levels of GAB1 and FOXP1 proteins in malignant and normal B cells, and this influences their BCR signalling.

Related Pathway/CSCs feature

Reference

  • [1] microRNA-150 inhibits human CD133-positive liver cancer stem cells through negative regulation of the transcription factor c-Myb.
    Zhang, J., et al. (2012). Int J Oncol 40(3): 747-756. [ 22025269 ]

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