Detail for microRNA 150

Full Name

microRNA 150

Gene Name



Related Disease

  • Liver Cancer [ref.1]
  • Ovarian cancer [ref.2]

Therapy Method


miR-150 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference.
miR-150 functions in hematopoiesis; it regulates genes whose downstream products encourage differentiating stem cells towards becoming megakaryocytes rather than erythrocytes. It is also thought to control B and T cell differentiation, alongside mir-155.
miR-150 has been linked with a number of cancers including prostate cancer, in which it can be bio-accumulated and also possibly transferred from food sources. It is thought to promote cancer cell proliferation in gastric cancer and has also been found to be more than 50x overexpressed in osteosarcoma. The expression of miR-150 was shown to regulate levels of GAB1 and FOXP1 proteins in malignant and normal B cells, and this influences their BCR signalling.

Related Pathway/CSCs feature


  • [1] microRNA-150 inhibits human CD133-positive liver cancer stem cells through negative regulation of the transcription factor c-Myb.
    Zhang, J., et al. (2012). Int J Oncol 40(3): 747-756. [ 22025269 ]
  • [2] miR-150 enhances apoptotic and anti-tumor effects of paclitaxel in paclitaxel-resistant ovarian cancer cells by targeting Notch3.
    Oncotarget.2017 Aug 18;8(42):72788-72800. [ 29069826 ]

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