miR-150 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference.
miR-150 functions in hematopoiesis; it regulates genes whose downstream products encourage differentiating stem cells towards becoming megakaryocytes rather than erythrocytes. It is also thought to control B and T cell differentiation, alongside mir-155.
miR-150 has been linked with a number of cancers including prostate cancer, in which it can be bio-accumulated and also possibly transferred from food sources. It is thought to promote cancer cell proliferation in gastric cancer and has also been found to be more than 50x overexpressed in osteosarcoma. The expression of miR-150 was shown to regulate levels of GAB1 and FOXP1 proteins in malignant and normal B cells, and this influences their BCR signalling.