Detail for NRP1


Full Name

Neuropilin-1

Uniprot ID

Gene Name

NRP1

NCBI ID

Related Disease

  • Hepatic Cancer [ref.1]

Therapy Method

Function

The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Reference

  • [1] miRNA-148b suppresses hepatic cancer stem cell by targeting neuropilin-1.
    Liu, Q., et al. (2015). Biosci Rep 35(4). [ 25997710 ]

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