Detail for HOTAIR


Full Name

HOX transcript antisense RNA

Gene Name

HOTAIR

NCBI ID

Related Disease

  • Colorectal Cancer [ref.1]

Therapy Method

Function

HOX transcript antisense RNA (HOTAIR) is one of long non-coding RNAs (lncRNAs); it interacts with polycomb repressive complex 2 and is responsible for histone H3 lysine-27 trimethylation of the HOD locus. Furthermore, aberrant HOTAIR expression has been markedly associated with metastasis and poor clinical outcomes in different tumor types including breast cancer[1].

Related Pathway/CSCs feature

  • Not Detected

Reference

  • [1] Decreasing lncRNA HOTAIR expression inhibits human colorectal cancer stem cells.
    Dou, J., et al. (2016). Am J Transl Res 8(1): 98-108. [ 27069543 ]

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