Drug name: Anti-miR inhibitor


Anti-miR miRNA Inhibitors are chemically modified, single stranded nucleic acids designed to specifically bind to and inhibit endogenous microRNA (miRNA) molecules. These ready-to-use inhibitors can be introduced into cells using transfection or electroporation parameters similar to those used for siRNAs, and enable detailed study of miRNA biological effects.

Use of the Anti-miR miRNA Inhibitors enable miRNA functional analysis by down-regulation of miRNA activity. Specific experimental designs include: miRNA target site identification and validation, screening for miRNAs that regulate the expression of a gene, and screening for miRNAs that affect a cellular process.

Anti-miR InhibitorSchema



  • [1] Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells.
    Bourguignon, L. Y., et al. (2009). J Biol Chem 284(39): 26533-26546.. [ 19633292 ]
  • [2] MiR-629 promotes human pancreatic cancer progression by targeting FOXO3.
    Cell Death Dis.2017 Oct 26;8(10):e3154.. [ 29072689 ]
  • [3] miR-217 targeting DKK1 promotes-cancer-stem-cell properties via activation of the Wnt signaling pathway in hepatocellular carcinoma.
    Oncol Rep.2017 Oct;38(4):2351-2359.. [ 28849121 ]
  • [4] MicroRNA-449a maintains self-renewal in liver cancer stem-like cells by targeting Tcf3.
    Oncotarget.2017 Nov 27;8(66):110187-110200. [ 29299140 ]
  • [5] miR-3120-5p promotes colon cancer stem cell stemness and invasiveness through targeting Axin2.
    Biochem Biophys Res Commun.2018 Feb 5;496(2):302-308. [ 29307822 ]
  • [6] MiR-30-5p suppresses cell chemoresistance and stemness in colorectal cancer through USP22/Wnt/β-catenin signaling axis.
    J Cell Mol Med.2018 Oct 19. doi: 10.1111/jcmm.13968. [ 30338942 ]
  • [7] Suppressive role exerted by microRNA-29b-1-5p in triple negative breast cancer through SPIN1 regulation.
    Oncotarget.2017 Apr 25;8(17):28939-28958.. [ 28423652 ]
  • [8] MiR-23b controls ALDH1A1 expression in cervical cancer stem cells.
    BMC Cancer.2017 Apr 27;17(1):292.. [ 28449663 ]
  • [9] miR-196a-5p modulates gastric cancer stem cell characteristics by targeting Smad4.
    Int J Oncol.2017 Jun;50(6):1965-1976. [ 28440445 ]
  • [10] Inhibition of miR-155,a therapeutic target for breast cancer, prevented in cancer stem cell formation.
    Cancer Biomark.2018 Feb 6;21(2):383-392. [ 29103027 ]
  • [11] MiR-129-5p inhibits non-small cell lung cancer cell stemness and chemoresistance through targeting DLK1.
    Biochem Biophys Res Commun.2017 Aug 19;490(2):309-316.. [ 28619508 ]

Back to top