Drug name: Anti-miR inhibitor


Related CSCTT Targets

MIR21 [ref.1]MI0000077

Introduction

Anti-miR miRNA Inhibitors are chemically modified, single stranded nucleic acids designed to specifically bind to and inhibit endogenous microRNA (miRNA) molecules. These ready-to-use inhibitors can be introduced into cells using transfection or electroporation parameters similar to those used for siRNAs, and enable detailed study of miRNA biological effects.

Use of the Anti-miR miRNA Inhibitors enable miRNA functional analysis by down-regulation of miRNA activity. Specific experimental designs include: miRNA target site identification and validation, screening for miRNAs that regulate the expression of a gene, and screening for miRNAs that affect a cellular process.

Anti-miR InhibitorSchema

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Reference

  • [1] Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells.
    Bourguignon, L. Y., et al. (2009). J Biol Chem 284(39): 26533-26546.. [ 19633292 ]

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