Detail for let-7


Full Name

let-7

Gene Name

MIRLET7

NCBI ID

Related Disease

  • Pancreatic Cancer [ref.1]

Therapy Method

Function

The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans,and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs.miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF0000002). miRNAs are initially transcribed in long trans-cripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about ~70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference.

Related Pathway/CSCs feature

Reference

  • [1] Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression.
    Bao, B., et al. (2012). Cancer Res 72(1): 335-345.. [ 22108826 ]

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