Detail for microRNA 26a


Full Name

microRNA 26a

Gene Name

MIR26A1

NCBI ID

Related Disease

  • Pancreatic Cancer [ref.1]

Therapy Method

Function

The miR-26 microRNA is a small non-coding RNA that is involved in regulating gene expression. The miR-26 family is composed of miR-26a-1, miR-26a-2 and miR-26b located in chromosomes 3, 12 and 2, respectively. Pre-miR-26 with stem-loop structure is processed into mature miR-26 by a series of enzymes of intranuclear and intracytoplasm. The mature miRNA of miR-26a-1 and miR-26a-2 possesses the same sequence, with the exception of 2 different nucleotides in mature miR-26b. miR-26 appears to be a vertebrate specific microRNA and has now been predicted or experimentally validated in many vertebrate species.

Related Pathway/CSCs feature

Reference

  • [1] Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression.
    Bao, B., et al. (2012). Cancer Res 72(1): 335-345.. [ 22108826 ]

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