Drug name: SB-T-1214 + CMC2.24


Related CSCTT Targets

CD133high/CD44high cells [ref.1]

SB-T-1214

Cas.no PubChem ID
178250-23-2 10350612
Known Target
Structure
...
Introduction
SB-T-1214 is a new-generation taxoid, possesses significant activity against colon cancer spheroids induced by and enriched with drug resistant tumorigenic CD133high/CD44high cells and efficiently inhibited expression of the majority of stem cell-related genes. The long-term efficacy of SB-T-1214 against drug resistant colon tumors in vivo may be explained by the down-regulation of multiple stem cell-related genes in the tumorigenic cell population, in addition to its known efficacy as a mitotic poison against proliferating cancer cells.

CMC2.24

Cas.no PubChem ID
1528745-87-0, 1255639-43-0
Known Target
Structure
...
Introduction
CMC2.24 is a novel polyenolic zinc-binding curcuminoid, which has higher bioactivity, better solubility and no evidence of toxicity even at high doses than curcumin.

Reference

  • [1] Prostate cancer stem cell-targeted efficacy of a new-generation taxoid, SBT-1214 and novel polyenolic zinc-binding curcuminoid, CMC2.24. Botchkina, G. I., et al. (2013).PLoS One. 8(9):e69884.
    24086245. [ 24086245 ]

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