Drug name: NP-TRAIL + γ-radiation


Related CSCTT Targets

TRAIL-resistant glioma stem cells [ref.1]

TRAIL, TNFSF10

Cas.no PubChem ID
Known Target
Structure
...
Introduction
TRAIL, PDB ID: P50591. A type-II transmembrane homotrimeric protein that belongs to the TNF gene superfamily, is a promising candidate for cancer therapy because of its selective apoptotic effect in a wide variety of transformed cells without affecting normal cells. NP-TRAIL is covalently conjugating TRAIL to the surface of the iron oxide NP.

γ-radiation, Gamma ray

Cas.no PubChem ID
Known Target
Structure
...
Introduction
γ-radiation are used to treat some types of cancer, since the rays kill cancer cells also. In the procedure called gamma-knife surgery, multiple concentrated beams of gamma rays are directed to the growth in order to kill the cancerous cells. The beams are aimed from different angles to concentrate the radiation on the growth while minimizing damage to surrounding tissues.

Reference

  • [1] TRAIL conjugated to nanoparticles exhibits increased anti-tumor activities in glioma cells and glioma stem cells in vitro and in vivo. Perlstein, B., et al. (2013).Neuro Oncol. 15(1):29-40.
    23144078. [ 23144078 ]

Back to top