Drug name: Metformin + Gemcitabine + RT


Related CSCTT Targets

AMPKα1 [ref.1]Q13131

Metformin

Cas.no PubChem ID
657-24-9 4091
Known Target
5'-AMP-activated protein kinase subunit beta-1Q9Y478
Serine/threonine-protein kinase mTORP42345
Structure
...
Introduction
Metformin is an oral antidiabetic drug in the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes, in particular, in overweight and obese people and those with normal kidney function. Limited evidence suggests metformin may prevent the cardiovascular and possibly the cancer complications of diabetes.

Gemcitabine

Cas.no PubChem ID
95058-81-4 60750
Known Target
DNA
Ribonucleoside-diphosphate reductase large subunitP23921
Thymidylate synthaseP04818
UMP-CMP kinaseP30085
Structure
...
Introduction
Gemcitabine is a nucleoside analog used as chemotherapy. It is marketed as Gemzar® by Eli Lilly and Company. As with fluorouracil and other analogues of pyrimidines, the drug replaces one of the building blocks of nucleic acids, in this case cytidine, during DNA replication. The process arrests tumor growth, as new nucleosides cannot be attached to the “faulty” nucleoside, resulting in apoptosis (cellular “suicide”). Gemcitabine is used in various carcinomas: non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. It is being investigated for use in oesophageal cancer, and is used experimentally in lymphomas and various other tumor types.

Radio Therapy

Cas.no PubChem ID
Known Target
Structure
...
Introduction
Radiation therapy is therapy using ionizing radiation, generally as part of cancer treatment to control or kill malignant cells. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers.

Reference

  • [1] Radiosensitization of pancreatic cancer cells by metformin through the AMPK pathway. Fasih, A., et al. (2014).Radiat Res. 182(1):50-9.
    24909911. [ 24909911 ]

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