Drug name: Oxaliplatin + 5E1


Related CSCTT Targets

Sonic hedgehog protein [ref.1, 2]Q15465
Indian hedgehog protein [ref.1, 2]Q14623

Oxaliplatin

Cas.no PubChem ID
61825-94-3 6857599
Known Target
DNA
Structure
...
Introduction
Oxaliplatin undergoes nonenzymatic conversion to active derivatives via displacement of the labile oxalate ligand. Several transient reactive species are formed, including monoaquo and diaquo DACH platinum, which covalently bind with macromolecules. After activation, oxaliplatin binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and transcription. Cytotoxicity is cell-cycle nonspecific.

Anti-Hh monoclonal antibody 5E1

Cas.no PubChem ID
Known Target
Sonic hedgehog proteinQ15465
Indian hedgehog proteinQ14623
Structure
...
Introduction
Anti-Hh monoclonal antibody 5E1, which neutralizes the Shh and Ihh activity, was prepared from a hybridoma, which was purchased from the Iowa Hybridoma Bank. Inhibition of Hh signaling with 5E1 induced apoptosis after 48 h of exposure, although these CD34+ cell lines exhibited resistance to cytarabine (Ara-C).

Reference

  • [1] Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer. Song, Z., et al. (2011).PLoS One. 6(3):e17687.
    21394208. [ 21394208 ]
  • [2] Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells. Kobune, M., et al. (2009). Cancer Sci 100(5): 948-955.
    19245435. [ 19245435 ]

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