Drug name: Verapamil


Related CSCTT Targets

ABC transporter proteins [ref.1]

Verapamil

Cas.no PubChem ID
52-53-9 2520
Known Target
Voltage-dependent L-type calcium channel subunit alpha-1CQ13936
Voltage-dependent L-type calcium channel subunit alpha-1DQ01668
Voltage-dependent L-type calcium channel subunit alpha-1FO60840
Voltage-dependent L-type calcium channel subunit alpha-1SQ13698
Voltage-dependent L-type calcium channel subunit beta-1Q02641
Potassium voltage-gated channel subfamily H member 2Q12809
ATP-sensitive inward rectifier potassium channel 11Q14654
Introduction
A calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thuis reducing heart rate and blood pressure. Verapamil's mechanism of effect in cluster headache is thought to be linked to its calcium-channel blocker effect, but which channel subtypes are involved is presently not known.

Verapamil-Structure

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Reference

  • [1] High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition. Awad, O., et al. (2010).PLoS One. 5(11):e13943.
    21085683. [ 21085683 ]

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