Drug name: Verapamil + Doxorubicin


Related CSCTT Targets

ALDH-high cells [ref.1]

Verapamil

Cas.no PubChem ID
52-53-9 2520
Known Target
Voltage-dependent L-type calcium channel subunit alpha-1CQ13936
Voltage-dependent L-type calcium channel subunit alpha-1DQ01668
Voltage-dependent L-type calcium channel subunit alpha-1FO60840
Voltage-dependent L-type calcium channel subunit alpha-1SQ13698
Voltage-dependent L-type calcium channel subunit beta-1Q02641
Potassium voltage-gated channel subfamily H member 2Q12809
ATP-sensitive inward rectifier potassium channel 11Q14654
Structure
...
Introduction
A calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thuis reducing heart rate and blood pressure. Verapamil's mechanism of effect in cluster headache is thought to be linked to its calcium-channel blocker effect, but which channel subtypes are involved is presently not known.

Doxorubicin

Cas.no PubChem ID
23214-92-8 31703
Known Target
DNA
DNA topoisomerase 2-alphaP11388
Structure
...
Introduction
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix.

Reference

  • [1] High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition. Awad, O., et al. (2010).PLoS One. 5(11):e13943.
    21085683. [ 21085683 ]

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