Drug name: Carprofen

Related CSCTT Targets

COX-2 [ref.1]P35354


Cas.no PubChem ID
53716-49-7 2581
Known Target
Prostaglandin G/H synthase 2P35354
Prostaglandin G/H synthase 1P23219
Carprofen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity. In an in vitro study using canine cell cultures, carprofen demonstrated selective inhibition of COX-2 versus COX-1.




  • [1] The long-acting COX-2 inhibitor mavacoxib (Trocoxil inverted question mark) has anti-proliferative and pro-apoptotic effects on canine cancer cell lines and cancer stem cells.Pang, L. Y., et al. (2014). BMC Vet Res 10(1): 184.
    25190452. [ 25190452 ]

Back to top