Drug name: MK-5108


Related CSCTT Targets

Aurora A [ref.1]O14965

MK-5108, VX-689

Cas.no PubChem ID
1010085-13-8 24748204
Known Target
Aurora kinase AO14965
Introduction
MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM; 220- and 190-fold more selective for Aurora A than Aurora B/C.

MK-5108, VX-689-Structure

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Reference

  • [1] Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFĸB pathway. Chefetz, I., et al. (2011).Cell Cycle.10(13):2206-14.
    21623171. [ 21623171 ]

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