Drug name: Alisertib

Related CSCTT Targets

Aurora A [ref.1]O14965

Alisertib, MLN8237

Cas.no PubChem ID
1028486-01-2 24771867
Known Target
Aurora kinase AO14965
Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM; has >200-fold higher selectivity for Aurora A than Aurora B.

Alisertib, MLN8237-Structure



  • [1] The mitotic kinase Aurora--a promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. D'Assoro, A. B., et al. (2014).Oncogene. 33(5):599-610.
    23334326. [ 23334326 ]

Back to top