Drug name: Disulfiram


Related CSCTT Targets

ALDH1 [ref.1]P00352

Disulfiram

Cas.no PubChem ID
97-77-8 3117
Known Target
Aldehyde dehydrogenase, mitochondrialP05091
Dopamine beta-hydroxylaseP09172
Retinal dehydrogenase 1P00352
Introduction
Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Disulfiram-Structure

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Reference

  • [1] Suppressing glioblastoma stem cell function by aldehyde dehydrogenase inhibition with chloramphenicol or disulfiram as a new treatment adjunct: an hypothesis. Kast, R. E., et al. (2009)Curr Stem Cell Res Ther. 4(4):314-7.
    19500061. [ 19500061 ]

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