Drug name: AZD6244


Related CSCTT Targets

MEK1 [ref.1]Q02750
ERK1 [ref.1]P27361
ERK2 [ref.1]P28482

AZD6244, Selumetinib

Cas.no PubChem ID
606143-52-6 10127622
Known Target
Dual specificity mitogen-activated protein kinase kinase 1Q02750
Introduction
Selumetinib (AZD6244; ARRY-142886) is a potent, highly selective MEK1 inhibitor with IC50 of 14 nM, also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc.

AZD6244, Selumetinib-Structure

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Reference

  • [1] EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling. Chang, C. J., et al. (2011).Cancer Cell. 19(1):86-100.
    21215703. [ 21215703 ]

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