Drug name: Oncofid-​S


Related CSCTT Targets

CD44 [ref.1]P16070

Hyaluronic acid

Cas.no PubChem ID
9067-32-7 3084049
Known Target
CD44 antigenP16070
Intercellular adhesion molecule 1P05362
Hyaluronan mediated motility receptorO75330
Structure
...
Introduction
ONCOFID™-S is a new bioconjugate of hyaluronic acid (HA) with SN-38 (the CPT11 active metabolite), that support the validity of the drug delivery strategy implying the use of HA as macromolecular carrier of antineoplastic drugs, an approach based on the over-expression of its target CD44 (the receptor for HA-mediated motility) in a wide variety of cancers.

SN38

Cas.no PubChem ID
86639-52-3 104842
Known Target
DNA topoisomerase 1P11387
Structure
...
Introduction
SN-38 (7-ethyl-10-hydroxycamptothecin) is the active metabolite of Irinotecan (CPT-11). SN-38 has been found to be 200–2000 times more cytotoxic than CPT-11, but has not been used as an anticancer drug due to its poor solubility in pharmaceutically acceptable solvents and low affinity to lipid membranes.

Reference

  • [1] CD44-targeting for antitumor drug delivery: a new SN-38-hyaluronan bioconjugate for locoregional treatment of peritoneal carcinomatosis. Serafino, A., et al. (2011).Curr Cancer Drug Targets. 11(5):572-85.
    21486216. [ 21486216 ]

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