Drug name: IM7-Saporin + PCI


Related CSCTT Targets

CD44 [ref.1]P16070

IM7-Saporin

Cas.no PubChem ID
Known Target
CD44 antigenP16070
Structure
...
Introduction
CD44 mAb (IM7) targets all isoforms of CD44, linked to the ribosome-inactivating protein saporin making the IT IM7-saporin. PCI (photochemical internalization) of IM7-saporin resulted in efficient and specific cytotoxicity in CD44-expressing but not in CD44-negative cancer cells.

Photochemical internalization

Cas.no PubChem ID
Known Target
Structure
...
Introduction

Reference

  • [1] Light-triggered, efficient cytosolic release of IM7-saporin targeting the putative cancer stem cell marker CD44 by photochemical internalization. Bostad, M., et al. (2014).Mol Pharm.11(8):2764-76.
    24960585. [ 24960585 ]

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