Drug name: CDF


Related CSCTT Targets

EZH2 [ref.1, 2]Q15910
EpCAM [ref.2, 3]P16422
HIF-1α [ref.2, 4]Q16665
Nanog [ref.2]Q9H9S0
VEGF [ref.2]P15692
IL6 [ref.2]P05231
Oct4 [ref.2]Q01860
microRNA 146 [ref.3]
microRNA 200b [ref.3]
microRNA 200c [ref.3]
microRNA 210 [ref.2]
microRNA 26a [ref.3]
microRNA 101 [ref.3]
let7 [ref.3]

Curcumin-difluorinated, CDF

Cas.no PubChem ID
1170354-22-9 54597187
Introduction
A novel synthetic derivative of curcumin and a known natural antitumor agent, on cell survival, clonogenicity, sphere-forming capacity, cell migration and invasion, CSC self-renewal capacity.

Curcumin-difluorinated, CDF-Structure

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Reference

  • [1] Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression. Bao, B., et al. (2012).Cancer Res.72(1):335-45.
    22108826. [ 22108826 ]
  • [2] Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment. Bao, B., et al. (2012).PLoS One. 7(12):e50165.
    23272057. [ 23272057 ]
  • [3] Hypoxia induced aggressiveness of prostate cancer cells is linked with deregulated expression of VEGF, IL-6 and miRNAs that are attenuated by CDF. Bao, B., et al. (2012).PLoS One.7(8):e43726.
    22952749. [ 22952749 ]

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