Drug name: DFMO


Related CSCTT Targets

ERBB2 [ref.1]P04626

Eflornithine, DFMO

Cas.no PubChem ID
70052-12-9 3009
Known Target
Ornithine decarboxylaseP11926
Introduction
Eflornithine (α-difluoromethylornithine or DFMO) is a drug found to be effective in the treatment of facial hirsutism (excessive hair growth) as well as in African trypanosomiasis (sleeping sickness). Eflornithine hydrochloride cream for topical application is meant for women suffering from facial hirsutism. DFMO is a “suicide inhibitor", irreversibly binding to Ornithine decarboxylase (ODC) and preventing the natural substrate ornithine from accessing the active site.

Eflornithine, DFMO-Structure

...

Reference

  • [1] Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047. Cirenajwis, H., et al. (2010).Anticancer Drugs.21(10):897-906.
    20838207. [ 20838207 ]

Back to top