Drug name: Carfilzomib + Reversin 121


Related CSCTT Targets

ABCB1 [ref.1]P08183

Carfilzomib

Cas.no PubChem ID
868540-17-4 11556711
Known Target
Proteasome subunit beta type-5P28074
Proteasome subunit beta type-8P28062
Proteasome subunit beta type-1P20618
Proteasome subunit beta type-9P28065
Proteasome subunit beta type-2P49721
Proteasome subunit beta type-10P40306
Structure
...
Introduction
Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. It is a substrate of ABCB1.

Reversin 121

Cas.no PubChem ID
174630-04-7 9939298
Known Target
Multidrug resistance protein 1P08183
Structure
...
Introduction
Reversin 121 is a high affinity peptide chemosensitizer interact with the P-glycoprotein multidrug transporter (MDR1) in isolated membranes, reconstituted systems, and intact cells

Reference

  • [1] Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1. Hawley, T. S., et al. (2013).Am J Hematol. 88(4):265-72.
    23475625. [ 23475625 ]

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