Drug name: Carfilzomib + Vismodegib


Related CSCTT Targets

ABCB1 [ref.1]P08183

carfilzomib

Cas.no PubChem ID
868540-17-4 11556711
Known Target
Proteasome subunit beta type-5P28074
Proteasome subunit beta type-8P28062
Proteasome subunit beta type-1P20618
Proteasome subunit beta type-9P28065
Proteasome subunit beta type-2P49721
Proteasome subunit beta type-10P40306
Structure
...
Introduction
Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. It is a substrate of ABCB1.

Vismodegib

Cas.no PubChem ID
879085-55-9 24776445
Known Target
Smoothened homologQ99835
Structure
...
Introduction
Vismodegib inhibits the hedgehog signalling pathway and is indicated for treatment of adult basal cell carcinoma.

Reference

  • [1] Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1. Hawley, T. S., et al. (2013).Am J Hematol. 88(4):265-72.
    23475625. [ 23475625 ]

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