Drug name: Mitomysin + Cyclopamine


Related CSCTT Targets

SMO [ref.1]Q99835

Mitomysin

Cas.no PubChem ID
50-07-7 5746
Known Target
DNA
Structure
...
Introduction
Mitomycin is activated in vivo to a bifunctional and trifunctional alkylating agent. Binding to DNA leads to cross-linking and inhibition of DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.

Cyclopamine

Cas.no PubChem ID
4449-51-8 442972
Known Target
Smoothened homologQ99835
Structure
...
Introduction
Cyclopamine is naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. Cyclopamine is currently being investigated as a treatment agent in basal cell carcinoma, medulloblastoma, and rhabdomyosarcoma, tumors that result from excessive Hh activity, glioblastoma, and as a treatment agent for multiple myeloma. It is currently under phase I of clinical trial.

Reference

  • [1] Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer. Song, Z., et al. (2011).PLoS One.6(3):e17687.
    21394208. [ 21394208 ]

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