Drug name: Vismodegib

Related CSCTT Targets

SMO [ref.1]Q99835

GDC0449, Vismodegib

Cas.no PubChem ID
879085-55-9 24776445
Known Target
Smoothened homologQ99835
Vismodegib selectively binds to and inhibits the transmembrane protein Smoothened homologue (SMO) to inhibit the Hedgehog signalling pathway.

GDC0449, Vismodegib-Structure



  • [1] Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs. Ahmad, A., et al. (2013).J Hematol Oncol. 6(1):77.
    24199791. [ 24199791 ]

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