Detail for microRNA 34a


Full Name

microRNA 34a

Gene Name

MIR34A

NCBI ID

Related Disease

  • Pancreatic Cancer [ref.1]
  • Gallbladder Cancer [ref.2]

Therapy Method

Function

he mir-34 microRNA precursor family are non-coding RNA molecules that, in mammals, give rise to three major mature miRNAs. The miR-34 family members were discovered computationally and later verified experimentally. The precursor miRNA stem-loop is processed in the cytoplasm of the cell, with the predominant miR-34 mature sequence excised from the 5' arm of the hairpin. The mature miR-34a is a part of the p53 tumor suppressor network; therefore, it is hypothesized that miR-34 dysregulation is involved in the development of some cancers.

Related Pathway/CSCs feature

Reference

  • [1] Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells.
    Nalls, D., et al. (2011). "" PLoS One 6(8): e24099.. [ 21909380 ]
  • [2] miR-34 is associated with poor prognosis of patients with gallbladder cancer through regulating telomere length in tumor stem cells.
    Jin, K., et al. (2014). Tumour Biol 35(2): 1503-1510.. [ 24078448 ]

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