Detail for microRNA 125b


Full Name

microRNA 125b

Gene Name

MIR125B

Related Disease

  • Glioblastoma [ref.1]

Therapy Method

Function

miR-125b, one of neuronal miRNAs, recently was found to be necessary for stem cell fission to bypass the normal G1/S checkpoint and make stem cells insensitive to chemotherapy signals, which normally stop the cell cycle at the G1/S transition. Given the insensitivity of gliomas to chemotherapy and the hypothesis that glioma stem cells cause resistance to drug therapy, exploring the functions and mechanisms of miR-125b in glioma stem cells would be valuable. This miRNA sequence is predicted based on homology to a verified miRNA from mouse. Its expression was later verified in human BC-1 cells.

Related Pathway/CSCs feature

Reference

  • [1] MiR-125b is critical for the suppression of human U251 glioma stem cell proliferation.
    Shi, L., et al. (2010). Brain Res 1312: 120-126.. [ 19948152 ]

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