Detail for microRNA 31


Full Name

microRNA 31

Gene Name

MIR31

NCBI ID

Related Disease

  • Non-Small Cell Lung Cancer [ref.1]

Therapy Method

Function

miR-31 has been characterised as a tumour suppressor miRNA, with its levels varying in breast cancer cells according to the metastatic state of the tumour. From its typical abundance in healthy tissue is a moderate decrease in non-metastatic breast cancer cell lines, and levels are almost completely absent in mouse and human metastatic breast cancer cell lines. There has also been observed a strong encapsulation of tumour cells expressing miR-31, as well as a reduced cell survival rate. miR-31's antimetastatic effects therefore make it a potential therapeutic target for breast cancer.

Related Pathway/CSCs feature

Reference

  • [1] Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo.
    Cufi, S., et al. (2013). Sci Rep 3: 2459.. [ 23963283 ]

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