Detail for microRNA 199b


Full Name

microRNA 199b

Gene Name

MIR199B

NCBI ID

Related Disease

  • Medulloblastoma [ref.1]

Therapy Method

Function

The miR-199 microRNA precursor is a short non-coding RNA gene involved in gene regulation. miR-199 genes have now been predicted or experimentally confirmed in mouse, human and a further 21 other species. microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. The mature products are thought to have regulatory roles through complementarity to mRNA.
 
MIR199B-5p originates from the 5-prime end of the MIR199B stem-loop structure. In a panel of 14 human tissues, highest MIR199B-5p expression was detected in right ventricle. High expression was also detected in duodenum, lymph nodes, lung, skeletal muscle, kidney, total heart, and thyroid. Lower expression was detected in all other tissues examined.

Related Pathway/CSCs feature

Reference

  • [1] MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma.
    Garzia, L., et al. (2009). PLoS One 4(3): e4998.. [ 19308264 ]

Back to top