Detail for microRNA 29b


Full Name

microRNA 29b

Gene Name

MIR29B

Related Disease

  • Ovarian Cancer [ref.1]

Therapy Method

Function

The miR-29 microRNA precursor, or pre-miRNA, is a small RNA molecule in the shape of a stem-loop or hairpin. Each arm of the hairpin can be processed into one member of a closely related family of short non-coding RNAs that are involved in regulating gene expression. The processed, or "mature" products of the precursor molecule are known as microRNA (miRNA), and have been predicted or confirmed in a wide range of species.

miR-29b was revealed to induce global DNA hypomethylation and tumor suppressor gene reexpression by directly targeting DNA methyltransferase (Dnmt) 3a and 3b expression and indirectly targeting Dnmt1 expression.

Related Pathway/CSCs feature

Reference

  • [1] The anti-chemoresistant effect and mechanism of MUC1 aptamer-miR-29b chimera in ovarian cancer.
    Dai, F., et al. (2013). Gynecol Oncol 131(2): 451-459.. [ 23933187 ]

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