Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
 Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment.
Bao, B., et al. (2012). PLoS One 7(12): e50165.. [ 23272057 ]
 Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis.
Hu, T., et al. (2008). Cancer Res 68(16): 6533-6540. [ 18701476 ]