Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145.
 Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment.
Bao, B., et al. (2012). PLoS One 7(12): e50165.. [ 23272057 ]
 Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy.
Duda, D. G., et al. (2006). J Clin Oncol 24(9): 1449-1453. [ 16549839 ]
 Cancer Stem Cells Contribute to Angiogenesis and Lymphangiogenesis in Serous Adenocarcinoma of the Ovary
Angiogenesis. 2019 Aug;22(3):441-455.. [ 31161471 ]