Cas.no | PubChem ID |
97682-44-5 | 60838 |
Known Target | |
DNA topoisomerase 1 | P11387 |
DNA topoisomerase I, mitochondrial | Q969P6 |
Structure | |
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Introduction | |
Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin. |
Cas.no | PubChem ID |
912288-64-3 |
Known Target | |
ATP-binding cassette sub-family G member 2 | Q9UNQ0 |
Structure | |
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Introduction | |
An in vivo bioavailable and highly water soluble ( >100 mg/ml) diethylaminoacetate prodrug of YHO-13177 that reverses ABCG2-mediated irinotecan resistance in P388/BCRP and HCT116/BCRP xenograft mouse models, and suppresses tumor growth and significantly enhances the survival (100 or 200 mg/kg, i.p.). |