Detail for cAMP/Rac/Cortactin pathway

Full Name

cAMP signaling pathway

Gene Name

Related Disease

  • Melanoma [ref.1]
  • Breast Cancer [ref.1]
  • Cervical Cancer [ref.2]
  • Lung Cancer [ref.2]

Therapy Method


Sac-1004 was found to reorganize actin cytoskeleton at endothelial cell-cell junction to form cortical actin ring via cAMP/Rac/Cortactin pathway. This cortical actin ring enhanced cell-cell junction integrity by upregulation of junction proteins such as vascular endothelial (VE)-cadherin.

Related Pathway/CSCs feature


  • [1] Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice.
    Agrawal, V., et al. (2014). Oncotarget 5(9): 2761-2777.. [ 24811731 ]

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