Detail for NF-κB pathway


Full Name

NF-κappa B signaling pathway

Gene Name

NF-κB pathway

Related Disease

  • Breast Cancer [ref.1]

Therapy Method

Function

A subpopulation of Ewing’s sarcoma cells, from both human cell lines and human xenografts grown in immune deficient mice, which express high aldehyde dehydrogenase (ALDHhigh) activity and are enriched for clonogenicity, sphere-formation, and tumor initiation. The ALDHhigh cells are resistant to chemotherapy in vitro.

Related Pathway/CSCs feature

Reference

  • [1] Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells.
    Carmody, L. C., et al. (2012). J Biomol Screen 17(9): 1204-1210.. [ 22941295 ]

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