Several pathways including Wnt/β-catenin, Hedgehog, and Notch have been identified to be critical to the self-renewal behavior of CSCs. Furthermore, CSCs have been suggested to contribute to tumor resistance/relapse because chemotherapy and radiation therapy are incapable of eradicating them. Thus, targeting these selfrenewal pathways may provide an effective strategy to target CSCs and thereby overcome tumor resistance and reduce relapse. Several dietary compounds, such as curcumin, quercetin, and epigallocatechin-gallate, were found to be potentially against CSC self-renewal.