Detail for Wnt/β-catenin pathway


Full Name

Wnt/β-catenin signaling pathway

Gene Name

Related Disease

  • Breast Cancer [ref.1]

Therapy Method

Function

Several pathways including Wnt/β-catenin, Hedgehog, and Notch have been identified to be critical to the self-renewal behavior of CSCs. Furthermore, CSCs have been suggested to contribute to tumor resistance/relapse because chemotherapy and radiation therapy are incapable of eradicating them. Thus, targeting these selfrenewal pathways may provide an effective strategy to target CSCs and thereby overcome tumor resistance and reduce relapse. Several dietary compounds, such as curcumin, quercetin, and  epigallocatechin-gallate, were found to be potentially against CSC self-renewal.

Related Pathway/CSCs feature

Reference

  • [1] Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells.
    Li, Y., et al. (2010). Clin Cancer Res 16(9): 2580-2590.. [ 20388854 ]

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